Journal
CURRENT OPINION IN GASTROENTEROLOGY
Volume 29, Issue 3, Pages 305-311Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOG.0b013e32835faacc
Keywords
cholangiocarcinoma; endoscopy; radiofrequency ablation
Categories
Funding
- British Liver Trust
- Department of Health's National Institute for Health Research Biomedical Research Centres (NIHRBRC)
- AMMF - The Cholangiocarcinoma Charity
- Imperial College Healthcare Charity
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Purpose of review To describe the use of endobiliary radiofrequency ablation (RFA) in the treatment of malignant disease of the bile duct and offer a comprehensive review of the emerging evidence on the safety and effectiveness of this new technique. Recent findings Ex-vivo and in-vivo porcine studies have been reported, confirming the feasibility of the technique, gathering preliminary safety data and defining appropriate power settings for human studies. Moderate-sized case series have now reported the use of RFA in mixed cohorts of human individuals with pancreatic cancer, cholangiocarcinoma and other malignant diseases of the bile duct. Endoscopic and percutaneous approaches have both been investigated. Small case series of blocked self-expanding metal stent clearance using RFA have been published. Summary Intraductal RFA, via both endoscopic and percutaneous approaches, is feasible. Complication rates appear to be comparable with the current standard endoscopic and percutaneous approaches to palliation of malignant strictures of the bile duct. The current body of literature is germinal, but warrants the further investigation of planned clinical trials.
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