Journal
CURRENT OPINION IN GASTROENTEROLOGY
Volume 29, Issue 6, Pages 614-620Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOG.0b013e328365d30f
Keywords
autoimmunity; cytokines; dendritic cells; intestinal mucosa; regulatory T cells
Categories
Funding
- National Institutes of Health [DK056762, DK091222, AI102269]
- [T32 DK083251]
Ask authors/readers for more resources
Purpose of reviewThe purpose of this review is to summarize recent advances in the fields of intestinal T-regulatory cell (Treg) and tolerogenic dendritic cell subsets. Under homeostatic conditions, CD4(+) Tregs and tolerogenic dendritic cells function to maintain mucosal tolerance. Loss of immune homeostasis is the primary cause of intestinal abnormalities, including inflammatory bowel disease. Thus, an improved understanding of cellular mechanisms promoting tolerance will be critical for the development of more efficacious therapies to treat chronic intestinal inflammation.Recent findingsSignificant progress has been made in the past year in the study of mucosal Treg and dendritic cell populations. In particular, efforts have focused on the migration and differentiation of these cells in the intestinal mucosa, the functional consequences of cross-talk with the intestinal microbiome, mechanisms by which tolerogenic dendritic cells take up antigen, and regulation of retinoic acid synthesis.SummaryRecent studies examining tolerogenic cell populations of the intestinal mucosa highlight the progress in understanding the function, regulation, and cross-talk of Treg and dendritic cell populations, and their interactions with the gut microbiota. Scientific advances in these areas will undoubtedly lead to the development of more effective therapeutic strategies for intestinal abnormalities such as inflammatory bowel disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available