Multiscale models for biological systems

Life, amazingly rich in diversity of shapes and functions, explores the limits of extreme complexity in nature. In this review we shall discuss in general terms the use of multiscale mathematical and computer models to study the dynamics of biological systems. These models permit integration of the rapidly expanding knowledge concerning the molecular basis of biology and its complex, nonlinear relationship with the emerging shapes and functions of cells, tissues and organs in living organisms. (C) 2009 Elsevier Ltd. All rights reserved.