Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 17, Issue 4, Pages 324-328Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0000000000000065
Keywords
inflammation; senescence; senescence-associated secretory phenotype
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Funding
- NIH [AG013925, AG041122, AG31736]
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Purpose of review Possible mechanisms in cellular senescence and the senescence-associated secretory phenotype ( SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered. Recent findings A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging. Summary Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.
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