Journal
JOURNAL OF NEUROSCIENCE
Volume 35, Issue 38, Pages 13219-13232Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0933-15.2015
Keywords
direction selectivity; retina; starburst amacrine cell; synaptic excitation; synaptic inhibition; vesicular GABA transporter
Categories
Funding
- National Institutes of Health [R01 EY024016]
- E. Matilda Ziegler Foundation
- Whitehall
- Sloan Research
- Karl Kirchgessner Foundation
- Brinson Foundation
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Direction selectivity of direction-selective ganglion cells (DSGCs) in the retina results from patterned excitatory and inhibitory inputs onto DSGCs during motion stimuli. The inhibitory inputs onto DSGCs are directionally tuned to the antipreferred (null) direction and therefore potently suppress spiking during motion in the null direction. However, whether direction-selective inhibition is indispensable for direction selectivity is unclear. Here, we selectively eliminated the directional tuning of inhibitory inputs onto DSGCs by disrupting GABA release from the presynaptic interneuron starburst amacrine cell in the mouse retina. We found that, even without directionally tuned inhibition, direction selectivity can still be implemented in a subset of On-Off DSGCs by direction-selective excitation and a temporal offset between excitation and isotropic inhibition. Our results therefore demonstrate the concerted action of multiple synaptic mechanisms for robust direction selectivity in the retina.
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