Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 16, Issue 1, Pages 27-32Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0b013e328359efd7
Keywords
anorexia; cachexia; cholecystokinin; ghrelin; leptin
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Funding
- Purina (Nestle)
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Purpose of review Anorexia represents a major problem for older persons leading to weight loss, sarcopenia, functional decline, and mortality. There is increasing information on the pathophysiological mechanisms that lead to anorexia. Recent findings Increasing evidence has shown the importance of gastrointestinal hormones (ghrelin, cholecystokinin, and glucagon-like peptide) and adipokines in producing the anorexia of aging. Numerous neurotransmitters have been shown to be involved in this aging anorexia, but evidence in humans is lacking. Summary The early recognition of anorexia of aging is important to allow intervention and prevent functional deterioration in older persons. Screening tests for anorexia have been developed. New approaches to managing anorexia are being tested.
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