Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 15, Issue 2, Pages 112-116Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0b013e32834f4598
Keywords
fatty acids; GPR119; GPR120; GPR40; GPR43
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Funding
- Fundacao de Apoio a Pesquisa do Estado de Sao Paulo (FAPESP)
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Purpose of review It has been demonstrated that fatty acids (FAs) are physiological ligands of G-protein-coupled receptors (GPRs). Activation of the GPRs (40, 41, 43, 84, 119 and 120) by FAs or synthetic agonists modulates several responses. In this review, we discuss the current knowledge on the actions of FA-activated GPRs and their relevance in normal and pathological conditions. Recent findings Studies have shown that FA-activated GPRs modulate hormone secretion (incretin, insulin and glucagon), activation of leukocytes and several aspects of metabolism. Summary Understanding GPR actions and their involvement in the development of insulin-resistance, beta-cell failure, dyslipidemia and inflammation associated with obesity, type 2 diabetes, metabolic syndrome and cardiovascular diseases is important for the comprehension of the mechanisms underlying these pathological conditions and for the establishment of new and effective interventions.
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