Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 11, Issue 3, Pages 303-308Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0b013e3282f795cf
Keywords
chondrocytes; growth; growth without growth hormone; leptin
Categories
Ask authors/readers for more resources
Purpose of review Leptin, first identified as the product of the ob gene in leptin-deficient obese (ob/ob) mice, was originally described as a circulating hormone involved in feeding behavior and energy homeostasis. It was later found to be a pleiotropic hormone involved in the regulation of a variety of physiological processes. This review summarizes our recent understanding of the role of leptin as a linear growth-stimulating factor. Recent findings Leptin was found to have mitogenic effects on numerous cell types in vivo and in vitro, including several cancer cells, cells of the immune system, as well as chondrocytes of the epiphyseal growth plate. Summary Leptin stimulates linear growth by regulating the energy balance of the organism and by stimulating the production and secretion of growth hormone from the hypothalamus; at the same time, it is involved with bone remodeling and has a direct effect on the chondrocytes of the growth plate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available