Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 19, Issue -, Pages 50-58Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2013.12.015
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Funding
- National Science Foundation [MOB 1122977]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1122977] Funding Source: National Science Foundation
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A subset of biological Fe S clusters contain protein-based ligands other than cysteine (Cys). The most common alternative ligand is histidine, while aspartate, arginine, and threonine ligation have also been identified. With the exception of the 2-Cys, 2-His ligated Rieske clusters, the functions of these uniquely ligated clusters are, in general, poorly understood. Recent functional studies of a set of 3-Cys, 1-His ligated [2Fe-2S] clusters have begun to highlight the importance of non-Cys ligation in controlling both the redox and chemical properties of these clusters as well as their physiological stability. Here, a survey of non-Cys ligation motifs is examined along with the possible biological roles of these clusters.
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