Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 18, Issue -, Pages 87-94Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2014.01.007
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Funding
- UK MRC [G0600512]
- UK Research Councils Basic Technology Initiative Glycoarrays [GRS/79268]
- Translational Grant [EP/G037604/1]
- NCI Alliance of Glycobiologists for Detection of Cancer and Cancer Risk [U01 CA128416]
- Wellcome Trust [WT093378MA/Z/10/Z, WT099197/Z/12/ZMA]
- BBSRC [BB/E02520X/1]
- Fundacao para a Ciencia e Tecnologia (FCT) [PEst-C/EQB/LA0006/2013]
- BBSRC [BB/E02520X/1] Funding Source: UKRI
- EPSRC [EP/G037604/1] Funding Source: UKRI
- MRC [G0600512] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E02520X/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [GR/S79268/02, EP/G037604/1] Funding Source: researchfish
- Medical Research Council [G0600512] Funding Source: researchfish
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The neoglycolipid (NGL) technology is the basis of a state-of-the-art oligosaccharide microarray system. The NGL-based microarray system in the Glycosciences Laboratory Imperial College London (http://www3.imperial.ac.uk/glycosciences) is one of the two leading platforms for glycan microarrays, being offered for screening analyses to the broad biomedical community. Highlighted in this review are the sensitivity of the analysis system and, coupled with mass spectrometry, the provision for generating 'designer' microarrays from glycomes to identify novel ligands of biological relevance. Among recent applications are assignments of ligands for apicomplexan parasites, pandemic 2009 influenza virus, polyoma and reoviruses, an innate immune receptor against fungal pathogens, Dectin-1, and a novel protein of the endoplasmic reticulum, malectin; also the characterization of an elusive cancer-associated antigen. Some other contemporary advances in glycolipid-containing arrays and microarrays are also discussed.
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