Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 17, Issue 3, Pages 385-392Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2013.03.029
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The immune system, and in particular T cells, can be harnessed to treat cancer. Several bispecific T cell engaging antibodies of the BiTE (R) format are in early or late-stage clinical development. These small recombinant antibody constructs effectively trigger killing of cancer cells by temporarily attached, polyclonal T cells. Blinatunnomab, a CD19/CD3-bispecific BiTE (R) antibody, has demonstrated high clinical activity in B cell leukemia and lymphoma patients. Three additional BiTE antibodies directed against surface target antigen expressed on solid tumors are being evaluated in phase I clinical trials. Alternative approaches to direct polyclonal T cells to kill cancer cells are under intense investigation.
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