Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 17, Issue 3, Pages 472-479Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2013.03.034
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Funding
- University of California, Berkeley
- Energy Biosciences Institute
- Camille and Henry Dreyfus Foundation
- Arnold and Mabel Beckman Foundation
- Dow Sustainable Products and Solutions Program
- Agilent Foundation
- Hellman Family Foundation
- National Science Foundation
- National Institutes of Health
- Department of Energy
- Defense Advanced Research Projects Agency
- Direct For Mathematical & Physical Scien [0956161] Funding Source: National Science Foundation
- Division Of Chemistry [0956161] Funding Source: National Science Foundation
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Commercial fermentation processes have long taken advantage of the synthetic power of living systems to rapidly and efficiently transform simple carbon sources into complex molecules. In this regard, the ability of yeasts to produce ethanol from glucose at exceptionally high yields has served as a key feature in its use as a fuel, but is also limited by the poor molecular properties of ethanol as a fuel such as high water miscibility and low energy density. Advances in metabolic engineering and synthetic biology allow us to begin constructing new high-flux pathways for production of next generation biofuels that are key to building a sustainable pipeline for liquid transportation fuels.
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