Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 17, Issue 6, Pages 910-917Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2013.10.006
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Funding
- European Research Council (ERC) [321381]
- Cantons of Basel
- Swiss Confederation within the INTERREG IV A.20 tri-national research program
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Synthetic biology is the science of reassembling cataloged and standardized biological items in a systematic and rational manner to create and engineer functional biological designer devices, systems and organisms with novel and useful, preferably therapeutic functions. Synthetic biology has significantly advanced the design of complex genetic networks that can reprogram metabolic activities in mammalian cells and provide novel therapeutic strategies for future gene-based and cell-based therapies. Synthetic biology-inspired therapeutic strategies provide new opportunities for improving human health in the 21st century. This review covers the most recent synthetic mammalian circuits designed for therapy of diseases such as metabolic disorders, cancer, and immune disorders. We conclude by discussing current challenges and future perspectives for biomedical applications of synthetic mammalian gene networks.
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