Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 16, Issue 3-4, Pages 422-428Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2012.03.015
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Funding
- Public Welfare & Safety Research Program [2010-0020772]
- Basic Science Research Program [2009-0085182]
- Nano/Bio Science & Technology Program through the National Research Foundation of Korea (NRF) [2005-01333]
- Ministry of Education, Science and Technology
- National Research Foundation of Korea [2010-0020780] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Signal amplification in conventional enzyme-based biosensors is not high enough to achieve the ultrasensitive detection of biomolecules. In recent years, signal amplification has been improved by combining enzymatic reactions with redox cycling or employing multienzyme labels per detection probe. Electrochemical-chemical redox cycling and electrochemical-chemical-chemical redox cycling allow ultrasensitive detection simply by including one or two more chemicals in a solution without the use of an additional enzyme and/or electrode. Multiple horseradish peroxidase labels on magnetic bead carriers provide high signal enhancement along with a multiplex detection possibility. In both cases, the detection procedures are the same as those in conventional enzyme-based electrochemical sensors.
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