Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 16, Issue 1-2, Pages 74-83Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2012.01.006
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Funding
- Research Grants Council of Hong Kong [HKU1/07C, HKU7042/07P, HKU7049/09P, N_HKU752/09]
- Croucher Foundation
- University of Hong Kong
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Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway of the drugs. Mining potential protein targets inside the pathogen via metallomic/metalloproteomic approach and further characterization on the interactions of bismuth drugs with these targets laid foundation in understanding the mechanism of action of bismuth drugs. Such studies would be beneficial in rational design of new potential drugs.
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