Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 16, Issue 5-6, Pages 602-608Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2012.10.023
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Funding
- Grants-in-Aid for Scientific Research [23249004, 20117003] Funding Source: KAKEN
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Recently established rational design strategies for novel fluorescence probes, especially those based on photoinduced electron transfer and spirocyclization were reviewed. Based on these design strategies, various novel fluorescence probes were successfully developed including those for reactive oxygen species, reporter enzymes. Furthermore, in vivo cancer imaging techniques based on rationally designed activatable probes such as cancer-specific antibodies tagged with acidic-pH activatable fluorescence probes and peptidase activatable fluorescence probes were also discussed.
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