Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 16, Issue 3-4, Pages 268-277Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2012.06.007
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Funding
- Hartwell Foundation
- March of Dimes
- NSF Faculty Early Career Development (CAREER) Award [1151035]
- NIH Director's New Innovator Award [1DP2OD008586]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1151035] Funding Source: National Science Foundation
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New technologies have recently emerged that enable targeted editing of genomes in diverse systems. This includes precise manipulation of gene sequences in their natural chromosomal context and addition of transgenes to specific genomic loci. This progress has been facilitated by advances in engineering targeted nucleases with programmable, site-specific DNA-binding domains, including zinc finger proteins and transcription activator-like effectors (TALEs). Recent improvements have enhanced nuclease performance, accelerated nuclease assembly, and lowered the cost of genome editing. These advances are driving new approaches to many areas of biotechnology, including biopharmaceutical production, agriculture, creation of transgenic organisms and cell lines, and studies of genome structure, regulation, and function. Genome editing is also being investigated in preclinical and clinical gene therapies for many diseases.
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