Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 16, Issue 3-4, Pages 415-421Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2012.04.011
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Funding
- Canadian Institute for Health Research
- Natural Sciences and Engineering Research Council
- Ontario Research Fund
- US Department of Defense (DARPA)
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Nanomaterial-based biosensing strategies offer a number of advantages over traditional molecular diagnostic and cellular analysis techniques, including signal amplification, improved sensitivity and speed, and versatile sensing schemes that can be tailored to a desired target. In this article, we highlight a variety of nanomaterial-based sensors, and discuss the advantages of different nanomaterials compositions and probes of different biomolecular classes. Recent advances in the development of optical, electrical, or electrochemical transduction mechanisms are covered, with special regard to breakthroughs in sensitivity. The works reviewed herein emphasize the improvements that nanomaterials offer in the realm of diagnostic assays and make a solid case for further advancement with automation and multiplexing.
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