Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 15, Issue 4, Pages 497-504Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2011.05.018
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Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional sources through cultivation of microorganisms. Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies. However, to be of practical use for drug discovery, these concepts must be advanced beyond their current state.
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