Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 15, Issue 2, Pages 335-341Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2011.01.006
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Funding
- NIGMS [GM45844, F32GM085987]
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Iron-binding transcription factors are widespread throughout the bacterial world and to date are known to bind several types of cofactors, such as Fe2+, heme, or iron-sulfur clusters. The known chemistry of these cofactors is exploited by transcription factors, including Fur, FNR, and NsrR, to sense molecules such as Fe2+, gases (e.g. oxygen and nitric oxide), or reactive oxygen species. New structural data and information generated by genome-wide analysis studies have provided additional details about the mechanism and function of iron-binding transcription factors that act as sensors.
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