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Role of natural product diversity in chemical biology

Journal

CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 15, Issue 3, Pages 350-354

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2011.03.004

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Funding

  1. National Institutes of Health [R01CA138544, R03DA026562]

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Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules. Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of biomolecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development.

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