Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 15, Issue 2, Pages 211-219Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2010.12.002
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Funding
- Fundacion Ramon Areces
- Royal Society
- EPSRC
- BBSRC [BB/E004350/1] Funding Source: UKRI
- EPSRC [EP/G026688/1, EP/I500200/1, EP/E000614/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/C510824/1, BB/E004350/1, EGA17763] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/E000614/1, EP/D023335/1, GR/T26542/01, EP/I500200/1, EP/D023343/1, EP/G026688/1] Funding Source: researchfish
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Enzymes are able to perform a multitude of chemical and biochemical transformations with efficiencies that are typically unrivalled by chemical catalysts. However, these evolved systems may lack breadth or utility in other non-natural applications. Altering enzyme and protein scaffolds through covalent modification can expand the usefulness of native biocatalysts not only for synthetic application but also for therapeutic use. This review summarizes recent developments in the field of chemical modification of enzymes and how they can be applied to synthesis and biological research.
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