Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 15, Issue 6, Pages 760-767Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2011.10.007
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Funding
- A*STAR (Agency for Science, Technology and Research Singapore) Biomedical Research Council, A*STAR SSCC [SSCC10/024]
- Converging Research Center through the Ministry of Education, Science and Technology, Korea [2010K001410]
- TJ Park Science Fellowship
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The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.
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