Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 14, Issue 5, Pages 608-615Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2010.06.182
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Funding
- Army Research Office
- Office of Naval Research
- National Science Foundation
- Department of Energy
- National Institutes of Health
- Sloan Research Foundation
- Arizona State University
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001016]
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Researchers have been using DNA for the rational design and construction of nanoscale objects for nearly 30 years. Recently, 'scaffolded DNA origami' has emerged as one of the most promising assembly techniques in DNA nanotechnology with a broad range of applications. In the past two years alone, DNA origami has been used to assemble water-soluble probe tiles for label-free RNA hybridization, to study single-molecule chemical reactions, to probe distance-dependent multivalent ligand-protein binding effects, and to organize a variety of relevant molecules including proteins, carbon nanotubes, and metal nanoparticles. This review will recount the origin, evolution, and current status of this extremely versatile assembly technique.
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