Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 14, Issue 3, Pages 308-314Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2010.02.001
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Funding
- NIH [P41 GM076267]
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Existing drugs address a relatively narrow range of biological targets. As a result, libraries of drug-like molecules have proven ineffective against a variety of challenging targets, such as protein-protein interactions, nucleic acid complexes, and antibacterial modalities. In contrast, natural products are known to be effective at modulating such targets, and new libraries are being developed based on underrepresented scaffolds and regions of chemical space associated with natural products. This has led to several recent successes in identifying new chemical probes that address these challenging targets.
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