Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 14, Issue 2, Pages 238-246Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2009.10.003
Keywords
-
Categories
Funding
- EPRSC
- CISMo
- Association of Commonwealth Universities
- EPSRC [EP/E063942/1, EP/G004773/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G004773/1, EP/E063942/1] Funding Source: researchfish
Ask authors/readers for more resources
Useful probes of the intracellular environment are required for a wide range of bioactive species including metal ions, oxyanions and pH These probes need to be targeted to specific organelles (mitochondria, nucleus and lysosomes) in order to allow direct observation of the changes in these regions. Critical probe design features for luminescent lanthanide complexes are defined, together with a review of published sub-cellular localisation profiles Cell uptake by macropinocytosis has been demonstrated for a wide range of probes and the importance of minimising perturbation of cellular homeostasis emphasised, so that cell viability, proliferation and membrane permeability are not compromised.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available