Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 14, Issue 1, Pages 50-56Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2009.10.014
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Funding
- National Institutes of Health [GM079465, T32 GM066698]
- University of California at Berkeley
- Beckman, Packard, and Sloan foundations
- Amgen
- Howard Hughes Medical Institute
- Ministry of Science, Thailand
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As the primary consumers of oxygen within all aerobic organisms, mitochondria are a major source of cellular reactive oxygen species (ROS) derived from the in vivo chemistry of oxygen metabolism. Mitochondrial ROS have been traditionally implicated in aging and in a variety of pathologies, including cancer, neurodegeneration, and diabetes, but recent studies also link controlled mitochondrial ROS fluxes to cell regulation and signaling events. Progress in the development of mitochondrial-targeted fluorescent small-molecule indicators that detect specific ROS with high selectivity offers a promising approach for interrogating mitochondrial ROS production, trafficking, and downstream biological effects.
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