Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 14, Issue 6, Pages 693-704Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2010.08.011
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Funding
- NSF [CHE-0750303, EXP-LA 0731153, DMR-1006761]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1006761] Funding Source: National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0750303] Funding Source: National Science Foundation
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Whether in a glass chip or multi-well plate, differential array sensors are performed as a series of experiments and their output is compared among each other to obtain the differential signals evaluated by pattern recognition methods. To increase the practicality of performing a large number of experiments the sensor elements are often used as semi-wet gels displaying properties of both the solution and the solid state. Due to their semi-wet nature, such array sensors are easier to handle while offering a mechanical support, the affinity of hydrophilic matrices for water aids in analyte transport, and the tunable hydrophilic/hydrophobic nature of the matrices can be used adjusting the preference of the chemosensor membrane for different analytes.
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