Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 14, Issue 5, Pages 582-596Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2010.08.014
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Upconverting luminescent nanoparticles (UCNPs) display the unique property of emitting visible light following photoexcitation with near-infrared laser light. This results in features such as virtually zero autofluorescence of (biological) matter and easy separation of the emission peaks from stray light. Other features include rather narrow emission bands, very high chemical stability, the lack of bleaching, and the absence of blinking effects. This article reviews the work performed in the past few years with UCNPs in terms of surface modifications, bioconjugation, and optical (cellular) imaging.
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