Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 13, Issue 1, Pages 74-83Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2009.01.022
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Funding
- NIH [GM67804, GM54608]
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The radical AdoMet superfamily comprises a diverse set of >2800 enzymes that utilize iron-sulfur clusters and S-adenosylmethionine (SAM or AdoMet) to initiate a diverse set of radical-mediated reactions. The intricate control these enzymes exercise over the radical transformations they catalyze is an amazing feat of elegance and sophistication in biochemistry. This review focuses on the accumulating evidence for how these enzymes control this remarkable chemistry, including controlling the reactivity between the iron-sulfur cluster and AdoMet, and controlling the subsequent radical transformations.
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