Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 13, Issue 1, Pages 10-18Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2009.01.014
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Funding
- NIH [R01 GM052594, R01 GM060595, R01 GM065155, P01 GM071790]
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The (re)design of enzymes to catalyze 'new' reactions is a topic of considerable practical and intellectual interest. Directed evolution (random mutagenesis followed by screening/selection) has been used widely to identify novel biocatalysts. However, 'rational' approaches using either natural divergent evolution or computational predictions based on chemical principles have been less successful. This review summarizes recent progress in evolution-based and computation-based (re)design.
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