Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 12, Issue 4, Pages 389-399Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2008.06.015
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Funding
- National Institutes of Health [R01-GM68385]
- Office of Naval Research [N00014-02-1-0390]
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Many multidrug-resistant bacterial pathogens harbor large plasmids that encode proteins conferring resistance to antibiotics. Although the acquisition of these plasmids often enables bacteria to survive in the presence of antibiotics, it is possible that plasmids also represent a vulnerability that can be exploited in tailored antibacterial therapy. This review highlights three recently described strategies designed to specifically combat bacteria harboring such plasmids: inhibition of plasmid conjugation, inhibition of plasmid replication, and exploitation of plasmid-encoded toxin-antitoxin systems.
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