Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 12, Issue 3, Pages 281-291Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2008.04.603
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Several years ago small molecular weight protein-protein interaction (PPI) antagonists were considered as the Mount Everest in drug discovery and generally regarded as too difficult to be targeted. However, recent industrial and academic research has produced a great number of new antagonists of diverse PPIs. This review structurally analyses small molecular weight PPI antagonists and their particular targets as well as tools to discover such compounds. Besides general discussions there will be a focus on the PPI p53/mdm2.
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