Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 27, Issue -, Pages 109-116Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2013.10.003
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- U.S. National Institutes of Health
- American Heart Association
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Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.
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