Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 28, Issue -, Pages 16-27Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2014.01.003
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Funding
- University of Wyoming Agricultural Experiment Station's Competitive Grants Program
- Wyoming IDeA Networks for Biomedical Research Excellence (INBRE)
- NIGMS [R15GM106318]
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The size and shape of the nucleus are tightly regulated, indicating the physiological significance of proper nuclear morphology, yet the mechanisms and functions of nuclear size and shape regulation remain poorly understood. Correlations between altered nuclear morphology and certain disease states have long been observed, most notably many cancers are diagnosed and staged based on graded increases in nuclear size. Here we review recent studies investigating the mechanisms regulating nuclear size and shape, how mitotic events influence nuclear morphology, and the role of nuclear size and shape in subnuclear chromatin organization and cancer progression.
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