Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 30, Issue -, Pages 33-40Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2014.05.010
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Funding
- Intramural Research Program of the Center for Cancer Research, NCI, National Institutes of Health
- European Research Council (ERC)
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Directional guidance of migrating cells is relatively well explored in the reductionist setting of cell culture experiments. Here spatial gradients of chemical cues as well as gradients of mechanical substrate characteristics prove sufficient to attract single cells as well as their collectives. How such gradients present and act in the context of an organism is far less clear. Here we review recent advances in understanding how guidance cues emerge and operate in complex physiological settings.
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