Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 30, Issue -, Pages 99-111Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2014.07.003
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Funding
- U.S. Department of Defense [W81XWH-12-1-0018]
- Burroughs Wellcome Fund Career Award for Medical Scientists
- American Cancer Society [RSG-12-141-01-CSM]
- NIH/NCI [U01 CA155758]
- Jerome L. Greene Foundation
- Mary Kay Ash Foundation [036-13]
- Cindy Rosencrans Fund for Triple Negative Breast Cancer Research
- Breast Cancer Research Foundation
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Metastasis begins when tumors invade into surrounding tissues. In breast cancer, the study of cell interactions has provided fundamental insights into this complex process. Powerful intravital and 3D organoid culture systems have emerged that enable biologists to model the complexity of cell interactions during cancer invasion in real-time. Recent studies utilizing these techniques reveal distinct mechanisms through which multiple cancer cell and stromal cell subpopulations interact, including paracrine signaling, direct cell-cell adhesion, and remodeling of the extracellular matrix. Three cell interaction mechanisms have emerged to explain how breast tumors become invasive: epithelial-mesenchymal transition, collective invasion, and the macrophage-tumor cell feedback loop. Future work is needed to distinguish whether these mechanisms are mutually exclusive or whether they cooperate to drive metastasis.
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