Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 25, Issue 5, Pages 659-671Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2013.07.001
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Funding
- Netherlands Science Organization [NWO-VICI 918.11.626]
- Dutch Cancer Foundation [KWF 2008-4031]
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Key steps of cancer progression and therapy response depend upon interactions between cancer cells with the reactive tumour microenvironment. Intravital microscopy enables multimodal and multi-scale monitoring of cancer progression as a dynamic step-wise process within anatomic and functional niches provided by the microenvironment. These niches deliver cell-derived and matrix-derived signals that enable cell subsets or single cancer cells to survive, migrate, grow, undergo dormancy, and escape immune surveillance. Beyond basic research, intravital microscopy has reached preclinical application to identify mechanisms of tumour-stroma interactions and outcome. We here summarise how n-dimensional 'dynamic histopathology' of tumours by intravital microscopy shapes mechanistic insight into cell-cell and cell-tissue interactions that underlie single-cell and collective cancer invasion, metastatic seeding at distant sites, immune evasion, and therapy responses.
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