Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 25, Issue 5, Pages 613-618Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2013.05.006
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Funding
- USPHS [RO1 GM47214]
- Belgian American Education Foundation
- WBI World excellence scholarships
- NIH [5 T32 HL007950]
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Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions. Recent work has led to major insights into the molecular mechanisms by which these adhesions respond to forces to control cellular signaling pathways. We briefly summarize effects of forces on organs, tissues, and cells; and then discuss recent advances toward understanding molecular mechanisms.
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