Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 25, Issue 5, Pages 642-649Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2013.06.004
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- National Institute of Dental and Craniofacial Research at the National Institutes of Health
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The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depends profoundly on the dimensionality of the extracellular matrix (ECM). Here we review a number of evolving concepts revealed when cell migration is examined in different dimensions.
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