Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 25, Issue 1, Pages 72-77Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2012.10.016
Keywords
-
Categories
Funding
- NIH [R01GM098394]
- National Institute of General Medical Sciences [1121176]
- National Science Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1307613] Funding Source: National Science Foundation
Ask authors/readers for more resources
Centrioles are the key foundation of centrosomes and cilia, yet a molecular understanding of how they form has only recently begun to emerge. Building a fully functional centriole that can form a centrosome and cilium requires two cell cycles. Centriole building starts with procentriole nucleation, a process that is coordinated by the conserved proteins Plk4/Zyg-1, and Asterless/Cep1 52. Subsequently, Sas-6, a conserved procentriole protein, self-assembles to provide nine-fold symmetry to the centriole scaffold. The procentriole then continues to elongate into a centriole, a process controlled by Sas-4/CPAP and CP110. Then, centrioles recruit Sas-4-mediated pre-assembled centrosomal complexes from the cytoplasm to form the pericentriolar material (PCM). Finally, CP110 and its interacting proteins are involved in controlling the timing of centriole templating of the cilium.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available