Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 24, Issue 6, Pages 731-738Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2012.08.007
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Funding
- US National Institutes of Health (NIH) [5T32CA009370-29]
- Salk Institute Cancer Center Core Grant [P30 CA014195-38]
- NIH [GM087476]
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Intrinsic limits on cellular proliferation in human somatic tissue serves as a tumor suppressor mechanism by restricting cell growth in aged cells with accrued pre-cancerous mutations: This is accompanied by the potential cost of restricting regenerative capacity and contributing to cellular and organismal aging. Emerging data support a model where telomere erosion controls proliferative boundaries through the progressive change of telomere structure from a protected state, through two distinct states of telomere deprotection. In this model telomeres facilitate a controlled permanent cell cycle arrest with a stable diploid genome during differentiation and may serve as an epigenetic sensor of general stress in DNA metabolism processes.
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