Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 24, Issue 4, Pages 460-466Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2012.05.010
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Funding
- NIH [DK051996]
- ARRA supplement
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ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin-proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The current understanding, results, and open questions are discussed below for this intriguing and critical process of ERAD.
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