Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 24, Issue 3, Pages 431-438Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2012.03.004
Keywords
-
Categories
Funding
- Wellcome Trust [087551, 077707]
- EC FP6 funding through the EURASNET Network of Excellence
- Darwin Trust of Edinburgh studentship
- Federation of European Biochemical Societies
- European Molecular Biology Organization
- BBSRC [BB/D019621/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D019621/1] Funding Source: researchfish
Ask authors/readers for more resources
Pre-mRNA splicing requires the activities of several ATPases from the DEAH-box, DEAD-box and Ski2-like helicase families to control conformational rearrangements within the spliceosome. Recent findings indicate that several spliceosomal helicases can act at multiple stages of the splicing reaction, and information on how those multiple actions are controlled are emerging. The recently solved crystal structure of the DEAH-box helicase Prp43 provides novel insights into the similarities and differences between the three helicase families. Here we discuss the potential family-specific mechanisms of spliceosomal RNA helicases and their regulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available