Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 24, Issue 5, Pages 685-694Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2012.06.009
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Funding
- National Institutes of Health [R01GM087558, R01CA113733]
- MGH Research Scholars Award
- National Health and Medical Research Council of Australia
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It has long been appreciated that proliferation of many cells is inhibited by density, a phenomenon that is often attributed to cell-cell contact. The basic properties of this phenomenon were established in the 1960s, along with the observation that such density-dependence was also lost in transformed cells. The mechanistic basis of contact inhibition of proliferation (CIP) has been slower to reveal itself. Here we discuss recent progress in elucidating the roles that cell-cell adhesion molecules play as receptors for CIP and in characterising the intracellular signaling pathways that mediate adhesion-dependent proliferative inhibition.
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