Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 24, Issue 6, Pages 858-864Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2012.10.001
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Funding
- Swiss National Science Foundation [31003A_138177]
- HFSP Career Development Award [CDA0016/2008]
- European Research Council [260493]
- European Research Council (ERC) [260493] Funding Source: European Research Council (ERC)
- Swiss National Science Foundation (SNF) [31003A_138177] Funding Source: Swiss National Science Foundation (SNF)
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How are cell morphogenesis and cell cycle coordinated? The fission yeast is a rod-shaped unicellular organism widely used to study how a cell self-organizes in space and time. Here, we discuss recent advances in understanding how the cell acquires and maintains its regular rod shape and uses it to control cell division. The cellular body plan is established by microtubules, which mark antipodal growth zones and medial division. In turn, cellular dimensions are defined by the small GTPase Cdc42 and downstream regulators of vesicle trafficking. Yeast cells then repetitively use their simple rod shape to orchestrate the position and timing of cell division.
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