Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 24, Issue 2, Pages 194-201Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2011.11.013
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Funding
- Telethon Italian Association for Cancer Research (AIRC) [5/1000]
- Epigenomic MIUR-CNR
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Morphogens induce biological diversity by operating in a dose-dependent manner. Here we review recent evidences indicating that microRNAs (miRNAs) are ideally suited to serve the morphogen cause. miRNAs regulate the establishment of morphogen gradients, including TGF beta, Wnt and other growth factors by acting on their secretion, distribution and clearance. miRNA are also critical in receiving cells, establishing context-dependency and threshold responses. Moreover, miRNAs contributes to gene networks that transform the graded activity of a morphogen into robust cell fate decisions. Finally, we discuss in the perspective section the implication of the new ceRNA hypothesis for morphogen biology.
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