Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 23, Issue 5, Pages 515-522Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2011.07.001
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22570195, 23111534]
- Grants-in-Aid for Scientific Research [22570195] Funding Source: KAKEN
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The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place through cell adhesion. Through the efforts to understand embryonic or cellular morphogenesis, dynamic interactions between the AJ and actin filaments have become crucial issues to be addressed since actin association is essential for AJ development, remodeling and function. Here, I provide an overview of cadherin-actin interaction from morphological aspects and of possible molecular mechanisms revealed by recent studies.
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