Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 22, Issue 4, Pages 479-487Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2010.04.008
Keywords
-
Categories
Funding
- Netherlands Organisation for Scientific Research
Ask authors/readers for more resources
Three types of motors, myosins, kinesins, and cytoplasmic dynein, cooperate to transport intracellular membrane organelles. Transport of each cargo is determined by recruitment of specific sets of motors and their regulation. Targeting of motors to membranes often depends on the formation of large multiprotein assemblies and can be influenced by membrane lipid composition. Motor activity can be regulated by cargo-induced conformational changes such as unfolding or dimerization. The architecture and function of motor: cargo complexes can also be controlled by phosphorylation, calcium signaling, and proteolysis. The complexity of transport systems is further increased by mechanical and functional cross-talk between different types of motors on the same cargo and by participation of the same motor in the movement of different organelles.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available