Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 22, Issue 5, Pages 651-658Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2010.07.006
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Funding
- NIH [GM035527]
- Jane Coffin Childs Fund for Medical Research
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM035527, R01GM035527] Funding Source: NIH RePORTER
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Endothelial cells form cell-cell adhesive structures, called adherens and tight junctions, which maintain tissue integrity, but must be dynamic for leukocyte transmigration during the inflammatory response and cellular remodeling during angiogenesis. This review will focus on Vascular Endothelial (VE)-cadherin, an endothelial-specific cell-cell adhesion protein of the adherens junction complex. VE-cadherin plays a key role in endothelial barrier function and angiogenesis, and consequently VE-cadherin availability and function are tightly regulated. VE-cadherin also participates directly and indirectly in intracellular signaling pathways that control cell dynamics and cell cycle progression. Here we highlight recent work that has advanced our understanding of multiple regulatory and signaling mechanisms that converge on VE-cadherin and have consequences for endothelial barrier function and angiogenic remodeling.
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